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RUMANIL SYRUP Product Identification • Generic Name: Rumanil Syrup • Type: Ayurvedic Patent Medicine • Primary Indication Area: Joint health, musculoskeletal support, and relief from pain and inflammation. Therapeutic Indications • Provides relief from joint pain and stiffness. • Supports mobility and flexibility of joints. • Reduces inflammation and discomfort associated with arthritis or minor injuries. • Helps in strengthening bones and muscles. Key benefits: 1. Relieves Joint Pain – Helps reduce discomfort in knees, elbows, shoulders, and other joints. 2. Reduces Inflammation – Herbal ingredients work to calm swelling and tenderness. 3. Improves Flexibility & Mobility – Supports easier movement and reduces stiffness. 4. Strengthens Muscles & Bones – Contributes to overall musculoskeletal health. 5. Supports Arthritis Management – May help with symptoms of osteoarthritis or mild joint disorders. 6. Natural & Ayurvedic – Use traditionally formulations long term use Ingredient: Guggulu (Commiphora mukul) Key Phytoconstituents: 1. Guggulsterones (E & Z isomers) – main active compounds 2. Sterols & Diterpenoids – anti-inflammatory activity 3. Resins – provide therapeutic effects 4. Essential oils – minor anti-inflammatory and analgesic effects Mechanism of Action in Joint Health 1. Anti-inflammatory o Guggulsterones inhibit pro-inflammatory mediators (like TNF-α, IL-1β, and COX enzymes). o Reduces swelling, stiffness, and tenderness in joints. 2. Analgesic (Pain Relief) o Reduces pain associated with osteoarthritis, rheumatoid arthritis, and minor joint injuries. Salai Guggul (Boswellia serrata) Botanical Name: Boswellia serrata Common Name: Indian Frankincense Key Phytoconstituents: 1. Boswellic Acids (α, β, acetyl-boswellic acids) – main active anti-inflammatory compounds 2. Triterpenoids – support anti-inflammatory activity 3. Essential Oils – minor analgesic and anti-inflammatory effects Mechanism of Action in Joint Health 1. Anti-inflammatory o Boswellic acids inhibit 5-lipoxygenase (5-LOX), reducing leukotriene synthesis. o Helps control inflammation in arthritis, tendinitis, and joint swelling. 2. Analgesic (Pain Relief) o Reduces pain associated with osteoarthritis and rheumatoid arthritis. Chobchini (Smilax china) Botanical Name: Smilax china Common Name: Chobchini Key Phytoconstituents: 1. Saponins – main bioactive compounds, contribute to anti-inflammatory and detoxifying effects. 2. Flavonoids – provide antioxidant and anti-inflammatory properties. 3. Steroids & Triterpenoids – support anti-inflammatory and immune-modulatory activity. 4. Polyphenols – help reduce oxidative stress and support joint health. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Saponins and flavonoids inhibit pro-inflammatory mediators, reducing joint inflammation and swelling. • Helpful in conditions like arthritis and gout. 2. Analgesic (Pain Relief) • Reduces pain and discomfort associated with inflamed joints Ashwagandha (Withania somnifera) Botanical Name: Withania somnifera Common Name: Ashwagandha, Indian Ginseng, Winter Cherry Key Phytoconstituents: 1. Withanolides – steroidal lactones responsible for anti-inflammatory, adaptogenic, and immunomodulatory effects. 2. Alkaloids – contribute to stress reduction and neuroprotective activity. 3. Saponins – support anti-inflammatory and antioxidant actions. 4. Polyphenols – provide antioxidant and tissue-protective effects. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Withanolides and saponins inhibit inflammatory cytokines (e.g., TNF-α, IL-1β) and oxidative stress in joints. • Helps in arthritis, tendinitis, and joint swelling. 2. Analgesic (Pain Relief) • Reduces pain and discomfort in osteoarthritis and rheumatoid arthritis. Haldi (Curcuma longa) Botanical Name: Curcuma longa Common Name: Turmeric, Haldi Key Phytoconstituents: 1. Curcuminoids (Curcumin, Desmethoxycurcumin, Bisdemethoxycurcumin) – primary anti-inflammatory and antioxidant compounds. 2. Volatile Oils (Turmerone, Atlantone, Zingiberene) – provide minor analgesic and anti-inflammatory effects. 3. Polysaccharides & Phenolics – support joint health through antioxidant and tissue-protective effects. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Curcumin inhibits NF-κB, COX-2, and 5-LOX pathways, reducing pro-inflammatory cytokines and mediators. • Helps manage arthritis, joint swelling, and tendinitis. 2. Analgesic (Pain Relief) • Reduces pain and stiffness associated with osteoarthritis and rheumatoid arthritis. Nirgundi (Vitex negundo) Botanical Name: Vitex negundo Common Name: Nirgundi, Five-leaved Chaste Tree Key Phytoconstituents: 1. Flavonoids (Negundoside, Casticin, Vitexin) – contribute to anti-inflammatory and antioxidant effects. 2. Iridoid glycosides – provide analgesic and anti-inflammatory activity. 3. Essential oils (α-pinene, β-caryophyllene, cineole) – minor analgesic and anti-inflammatory effects. 4. Triterpenoids & Steroids – support joint health by modulating inflammation. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Flavonoids and iridoid glycosides inhibit inflammatory mediators like prostaglandins and leukotrienes. • Helps manage arthritis, joint swelling, and muscle inflammation. 2. Analgesic (Pain Relief) • Reduces pain associated with osteoarthritis, rheumatoid arthritis, and general joint discomfort. Rasna (Pluchea lanceolata / Pluchea indica) Botanical Name: Pluchea lanceolata (commonly) / Pluchea indica Common Name: Rasna Key Phytoconstituents: 1. Flavonoids (Quercetin, Kaempferol derivatives) – provide anti-inflammatory and antioxidant effects. 2. Terpenoids & Essential Oils – contribute analgesic and anti-inflammatory activity. 3. Alkaloids & Phenolics – support anti-inflammatory and tissue-protective functions. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Inhibits pro-inflammatory mediators like prostaglandins and leukotrienes. • Effective in arthritis, joint swelling, and musculoskeletal inflammation. 2. Analgesic (Pain Relief) • Reduces joint pain and discomfort associated with osteoarthritis and rheumatic conditions. Saunth (Zingiber officinale, dried ginger) Botanical Name: Zingiber officinale Common Name: Saunth, Dried Ginger Key Phytoconstituents: 1. Gingerols & Shogaols – primary anti-inflammatory and analgesic compounds. 2. Volatile Oils (Zingiberene, β-bisabolene, α-Curcumene) – support pain relief and anti-inflammatory effects. 3. Resins & Phenolic Compounds – provide antioxidant and tissue-protective activity. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Gingerols and shogaols inhibit COX and 5-LOX pathways, reducing pro-inflammatory prostaglandins and leukotrienes. • Helps manage arthritis, joint swelling, and tendon inflammation. 2. Analgesic (Pain Relief) • Reduces joint pain and stiffness associated with osteoarthritis and rheumatoid arthritis. Erandmool (Ricinus communis) Botanical Name: Ricinus communis Common Name: Castor Root, Erandmool Key Phytoconstituents: 1. Ricinoleic Acid – primary anti-inflammatory and analgesic compound. 2. Flavonoids & Phenolic Compounds – provide antioxidant and tissue-protective effects. 3. Triterpenoids & Sterols – support anti-inflammatory activity and joint tissue protection. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Ricinoleic acid and triterpenoids modulate inflammatory mediators like prostaglandins and cytokines. • Reduces joint swelling and inflammation in arthritis and musculoskeletal conditions. 2. Analgesic (Pain Relief) • Provides pain relief in osteoarthritis, rheumatoid arthritis, and general joint discomfort. Mulethi (Glycyrrhiza glabra) Botanical Name: Glycyrrhiza glabra Common Name: Mulethi, Licorice Root Key Phytoconstituents: 1. Glycyrrhizin – primary anti-inflammatory and tissue-protective compound. 2. Flavonoids (Liquiritin, Isoliquiritin, Glabridin) – antioxidant and anti-inflammatory effects. 3. Saponins & Phenolics – support cartilage protection and analgesic activity’s Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Glycyrrhizin and flavonoids modulate inflammatory cytokines and inhibit COX/LOX pathways. • Helps reduce arthritis-related inflammation, joint swelling, and musculoskeletal pain. 2. Analgesic (Pain Relief) • Reduces pain and discomfort in osteoarthritis and rheumatoid arthritis. Suranjan (Colchicum luteum / Colchicum autumnale) Botanical Name: Colchicum luteum (commonly in Ayurveda) / Colchicum autumnale Common Name: Suranjan Key Phytoconstituents: 1. Colchicine – primary anti-inflammatory and anti-gout compound. 2. Alkaloids & Phenolics – support anti-inflammatory and antioxidant effects. 3. Flavonoids & Saponins – provide tissue-protective and mild analgesic effects. Mechanism of Action in Joint Health: 1. Anti-inflammatory Effects • Colchicine inhibits microtubule polymerization, reducing neutrophil migration and inflammatory mediator release. • Highly effective in gouty arthritis, joint swelling, and acute inflammation. 2. Analgesic (Pain Relief) • Reduces pain in joints, especially in gout and acute inflammatory episodes.
